Carmen Coirry works at Bioscience & Bioengineering for Health (BGE) at CEA.

Her project: My research focuses on cell growth, proliferation and deubiquinating enzymes. .

Hello ! I am Carmen Coirry from Rennes, France. I am currently a PhD student at the BGE lab at CEA, working in the Genetics and Chemogenomics team under the supervision of Dr. Emmanuel Taillebourg and Dr. Marie-Odile Fauvarque. My research focuses on cell growth, proliferation and deubiquinating enzymes. 

As for my academic background, I earned a Bachelor’s degree in Cellular, Molecular Biology and Physiology, followed by a Master’s degree in Health Biology with a specialization in Experimental Physiology and Toxicology at the University of Brest (Brest, France). Throughout my studies and internships, I developed a stong interest in developmental genetics and regulatory systems, particularly the ubiquitin-proteasome system. 

Deubiquitinases belong to a specific class of proteases that remove ubiquitin from ubiquitinated proteins. They are involved in the regulation of many cellular processes, including cell growth and proliferation. Specifically, USP36 deubiquitinates the oncogenic transcription factor c-Myc, preventing its degradation by the proteasome. These two proteins form a conserved complex in eukaryotes, making Drosophila melanogaster an ideal genetically tractable model to study the mechanisms of USP36 in vivo. 

My PhD aims at understanding the precise role of dUSP36 in dMYC regulation, characterizing new proteins interacting with dUSP36 and explore a novel catalytic function of dUSP36 in spermatogenesis.

Outside the lab, I enjoy sport such as climbing or running, as well as spending time in the mountains, making Grenoble the perfect place for me.